Cell cycle: Will the real Cdk-activating kinase please stand up
نویسنده
چکیده
Activation of a cyclin-dependent kinase (Cdk) requires its association with a cyclin subunit and phosphorylation on a conserved residue by the Cdk-activating kinase (CAK). The discovery in budding yeast of a novel CAK that is structurally distinct from the CAKs of other eukaryotes raises questions about the 'true' CAK.
منابع مشابه
Roles of Cyclin Dependent Kinase and Cdk- Activating Kinase in Cell Cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization
Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. CDKs require cyclin binding activity, phosphorylation through CDK activating kinase (CAK), Cdc25, Wee 1 kinase. Non-cyclin CDK activators include CDK5 activators, Viral Cyclins and RINGO/Speedy. Among all CDK activators, CAK carries prime importance. The time frame of activating phosphorylation...
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عنوان ژورنال:
- Current Biology
دوره 7 شماره
صفحات -
تاریخ انتشار 1997